Content continues after advertisement

Differential Diagnosis: Thrombocytosis

Julie Allen, BVMS, MS, MRCVS, DACVIM (SAIM), DACVP, Cornell University

Internal Medicine

|July 2020|Peer Reviewed

Sign in to Print/View PDF

Differential Diagnosis: Thrombocytosis

Following are differential diagnoses for patients presented with thrombocytosis.

  • Drug-induced response (eg, to vincristine, epinephrine, possibly a glucocorticoid)
  • Iron deficiency
  • Physiologic reaction
    • To epinephrine (eg, due to trauma, exercise, or excitement)
    • Postsplenectomy
  • Primary thrombocytosis
    • Acute megakaryocytic leukemia
    • Chronic myeloproliferative disease
  • Chronic basophilic leukemia
  • Chronic myeloid leukemia
  • Essential thrombocythemia
  • Other myelodysplastic/ myeloproliferative neoplasm
  • Polycythemia vera
  • Primary myelofibrosis
  • Pseudothrombocytosis
    • RBC ghosts or fragments, fragile leukocytes, microorganisms, or lipemia
  • Reactive thrombocytosis
    • Hematopoietic/nonhematopoietic neoplasia
    • Hyperadrenocorticism
    • Infection
    • Inflammation (eg, immune-mediated or hepatobiliary disease)
    • Postsplenectomy
    • Rebound from thrombocytopenia
    • Trauma


For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

All Clinician's Brief content is reviewed for accuracy at the time of publication. Previously published content may not reflect recent developments in research and practice.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.


Clinician's Brief:
The Podcast

Listen as host Beckie Mossor, RVT, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Privacy Policy (Updated 05/08/2018) Terms of Use (Updated 05/08/2018)