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Differential Diagnosis: Thrombocytosis

Julie Allen, BVMS, MS, MRCVS, DACVIM (SAIM), DACVP, Cornell University

Internal Medicine

|July 2020|Peer Reviewed

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Differential Diagnosis: Thrombocytosis

Following are differential diagnoses for patients presented with thrombocytosis.

  • Drug-induced response (eg, to vincristine, epinephrine, possibly a glucocorticoid)
  • Iron deficiency
  • Physiologic reaction
    • To epinephrine (eg, due to trauma, exercise, or excitement)
    • Postsplenectomy
  • Primary thrombocytosis
    • Acute megakaryocytic leukemia
    • Chronic myeloproliferative disease
  • Chronic basophilic leukemia
  • Chronic myeloid leukemia
  • Essential thrombocythemia
  • Other myelodysplastic/ myeloproliferative neoplasm
  • Polycythemia vera
  • Primary myelofibrosis
  • Pseudothrombocytosis
    • RBC ghosts or fragments, fragile leukocytes, microorganisms, or lipemia
  • Reactive thrombocytosis
    • Hematopoietic/nonhematopoietic neoplasia
    • Hyperadrenocorticism
    • Infection
    • Inflammation (eg, immune-mediated or hepatobiliary disease)
    • Postsplenectomy
    • Rebound from thrombocytopenia
    • Trauma

References

For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

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