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Differential Diagnosis: Neutrophilia

Marie A. Chartier, DVM, DACVIM, BluePearl Pet Hospital, Charlestown, Massachusetts

Internal Medicine

|June 2021|Peer Reviewed

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Differential Diagnosis: Neutrophilia

Following are differential diagnoses for patients presented with an elevated neutrophil count.

  • Increased production associated with bone marrow response to inflammation
    • Infection (eg, bacterial, viral, fungal, protozoal) of any organ system 
    • Sterile inflammation (eg, immune-mediated disease, neoplasia, tissue trauma or necrosis) 
  • Increased production associated with bone marrow response to peripheral cytopenias (eg, hemolytic anemia, hemorrhagic anemia, thrombocytopenia) 
  • Glucocorticoid-associated
    • Stress (physical)
    • Glucocorticoid administration
    • Hyperadrenocorticism
  • Granulocytic leukemia
  • Specific infections causing severe leukemoid response 
    • Hepatozoonosis (Hepatozoon canis)
    • Babesiosis (Babesia canis)
  • Leukocyte adhesion deficiencies in dogs (eg, Irish setter), usually associated with hypersegmented neutrophils


For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

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