Content continues after advertisement

Differential Diagnosis: Monocytosis

Julie Allen, BVMS, MS, MRCVS, DACVIM (SAIM), DACVP, Cornell University

Internal Medicine

|October 2020|Peer Reviewed

Sign in to Print/View PDF

Differential Diagnosis: Monocytosis

Following are differential diagnoses for patients presented with monocytosis.* 

  • Chronic neutropenia
  • Granulocyte colony-stimulating factor administration
  • Increased endogenous or exogenous corticosteroids (especially in dogs)
  • Inflammation (eg, infectious vs noninfectious, acute vs chronic)
  • Monocytic or monoblastic leukemia (very rare)
  • Necrosis and/or tissue destruction (eg, from coccidioidomycosis or immune-mediated hemolytic anemia)
  • Paraneoplastic response with various tumors (associated with poor prognosis)
    • Lymphoma (ie, increased monocyte chemotactic protein; possible secretion of granulocyte-macrophage colony-stimulating factor)
    • Osteosarcoma
  • Recovery from acute bone marrow injury
    • Secondary to administration of a chemotherapeutic agent
    • Secondary to parvovirus infection (rare)
*Monocytopenia is not recognized as a clinically significant problem.


For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

All Clinician's Brief content is reviewed for accuracy at the time of publication. Previously published content may not reflect recent developments in research and practice.

Material from Clinician's Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.


Clinician's Brief:
The Podcast

Listen as host Beckie Mossor, RVT, talks with the authors of your favorite Clinician’s Brief articles. Dig deeper and explore the conversations behind the content here.
Clinician's Brief provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 9 years.*

*2007-2017 PERQ and Essential Media Studies

© Educational Concepts, L.L.C. dba Brief Media ™ All Rights Reserved. Privacy Policy (Updated 05/08/2018) Terms of Use (Updated 05/08/2018)