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Differential Diagnosis: Hypocholesterolemia

Julie Allen, BVMS, MS, MRCVS, DACVIM (SAIM), DACVP (Clinical), Durham, North Carolina

Internal Medicine

|March 2019|Peer Reviewed

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Following are differential diagnoses, listed in order of likelihood, for patients presented with hypocholesterolemia.

  • Severe icterus (false decrease)
  • Protein-losing enteropathy (eg, lymphangiectasia, inflammatory bowel disease, lymphoma, infectious agents such as Heterobilharzia americana)
  • Liver disease such as portosystemic shunt, ductal plate malformation, or liver failure (eg, secondary to toxins such as Sago palm)
  • Hypoadrenocorticism
  • Exocrine pancreatic insufficiency
  • Hemophagocytic syndrome; can be seen in association with a variety of infectious and noninfectious diseases, including immune-mediated diseases and certain tumors (due to decreased synthesis and/or increased catabolism secondary to inflammatory cytokines)
  • Histiocytic sarcoma (dogs)
  • Multiple myeloma (cats)
  • Acute myeloid leukemia
  • Lymphoma


For global readers, a calculator to convert laboratory values, dosages, and other measurements to SI units can be found here.

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