The Most Important (& Cool) New Drugs of 2016 & 2017

Lauren A. Trepanier , DVM, PhD, DACVIM, DACVCP, University of WisconsinMadison

The Most Important (& Cool) New Drugs of 2016 & 2017

This presentation highlights some new drugs addressing important veterinary therapeutic problems:

  • Alfaxalone is a short-acting injectable anesthetic with FDA approval for use in dogs and cats. Although similar to propofol, it may be given IM and may result in less cardiopulmonary depression.
  • Capromorelin is a ghrelin agonist that helps maintain appetite and lean body mass. It is FDA approved for appetite stimulation in dogs and has a wide safety margin.
  • Imepitoin is an anticonvulsant used in canine epilepsy. Its effectiveness is comparable to phenobarbital, but it has fewer side effects and does not induce liver enzymes.
  • Pimobendan is an effective positive inotrope and venodilator used in dogs with mitral valve disease and concurrent cardiomegaly, in dogs with dilated cardiomyopathy, and for empirical treatment of cats with cardiomyopathies.
  • Rabacfosadine has conditional FDA approval for treating canine lymphoma. It may be used as a single-agent therapy or combined with doxorubicin.
  • New drugs for treatment of atopic dermatitis include lokivetmab (dogs) and oclacitinib (dogs, off-label cats). Both target the Janus kinase pathway and have rapid onset of action.
  • Robenacoxib is an NSAID with FDA approval for use for acute pain in dogs and cats. One study showed it was well tolerated in cats with osteoarthritis treated for 1 month. However, it should not be used for more than 3 days in dogs.
  • Grapiprant is an NSAID-like drug that is FDA approved for pain and inflammation caused by osteoarthritis in dogs. It should not be combined with glucocorticoids or other NSAIDs.

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