Most feline patients are random-bred domestic cats; random breeding propagates and disperses evolutionarily ancient disease-liability genes, which causes the random development of clinical genetic disease. Pedigreed breeds may have varied incidence of disease, depending on the frequencies of liability genes in their gene pools. Insurance claims and centralized hospital databases monitor the most frequent disease presentations, which helps veterinarians understand the most frequent genetic diseases.1-3 The most frequent conditions are complexly inherited and involve combinations of multiple genes and environmental factors. Genetic diseases should be recognized in practice because they must be treated as chronic illnesses—not episodic diseases. 


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