ISSUE

“RECENT SHORTAGES OF DOXYCYCLINE HAVE LED TO PRICE INCREASES; I NEED AN ALTERNATIVE.”

Commercial suspensions of doxycycline are expensive and only stable for 2 weeks once reconstituted. Compounded doxycycline in aqueous vehicles is typically only stable for 7 days and is associated with a high risk for treatment failure from unstable product.1

ANSWER 

CONSIDER MINOCYCLINE

Minocycline and doxycycline are semisynthetic antibiotics in the tetracycline family. Both are bacteriostatic; prevent bacterial growth by interfering with protein synthesis; and have antibacterial, anti-inflammatory, neuroprotective, cytoprotective,2,3 antiprotozoal, and anthelmintic effects,4,5 but there are important differences to consider.  


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