Low-Dose Dexamethasone Suppression Testing for Hyperadrenocorticism

Laura V. Lane, DVM, & Theresa E. Rizzi, DVM, Diplomate ACVP, Oklahoma State University

Profile

Definition
Hyperadrenocorticism in dogs, also called canine Cushing’s syndrome (CCS), is a clinical syndrome with biochemical abnormalities resulting from excess cortisol production by the adrenal glands.1,2

The prevalence of CCS in the general population of dogs in the United States is approximately 0.1%.3

The initial index of suspicion results from history, clinical signs, and a minimum database; it should not be diagnosed without endocrine testing.1,3-6

The normal regulation of cortisol (Figure 1): Corticotropin-releasing hormone (CRH) from the hypothalamus stimulates the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary. ACTH in turn stimulates the secretion of cortisol from the adrenal cortex. Cortisol exerts negative feedback on both ACTH and CRH secretion. 

Sign in to continue reading this article.

Not registered? Create an account for free to read full articles from cliniciansbrief.com.

Material from Clinician’s Brief may not be reproduced, distributed, or used in whole or in part without prior permission of Educational Concepts, LLC. For questions or inquiries please contact us.

Clinician’s Brief, the official publication of the NAVC, provides relevant diagnostic and treatment information for small animal practitioners. It has been ranked the #1 most essential publication by small animal veterinarians for 7 years.*

*2007-2013 PERQ and Essential Media Studies