Hyperadrenocorticism in dogs, also called canine Cushing’s syndrome (CCS), is a clinical syndrome with biochemical abnormalities resulting from excess cortisol production by the adrenal glands.1,2

The prevalence of CCS in the general population of dogs in the United States is approximately 0.1%.3

The initial index of suspicion results from history, clinical signs, and a minimum database; it should not be diagnosed without endocrine testing.1,3-6

The normal regulation of cortisol (Figure 1): Corticotropin-releasing hormone (CRH) from the hypothalamus stimulates the release of adrenocorticotropic hormone (ACTH) from the anterior pituitary. ACTH in turn stimulates the secretion of cortisol from the adrenal cortex. Cortisol exerts negative feedback on both ACTH and CRH secretion. 

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