December 2012
Toxicology
Peer Reviewed

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Definition

  • When ivermectin, a macrocytic lactone, is present in sufficiently high concentrations to cross the blood–brain barrier, it can cause neurologic signs in dogs. 
  • Toxicity may occur with products administered orally, topically, or parenterally. 
    • The same dose will be absorbed faster when administered parenterally than when administered topically, but signs of toxicity can be seen in all routes with high enough doses.
  • The same dose will be absorbed faster when administered parenterally than when administered topically, but signs of toxicity can be seen in all routes with high enough doses.

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