Chronic ulcerative paradental stomatitis (CUPS)—also known as ulcerative stomatitis, idiopathic stomatitis, lymphocytic plasmacytic stomatitis, and plaquereactive stomatitis—is a painful and often debilitating disease involving mucosal areas that contact plaque and calculus in predisposed dogs.

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Paradental refers to the mucous membranes on the inside of the lips and cheeks, palate, and tongue.1 The inflammatory lesions do not include the teeth and rarely include the attached gingiva unless accompanied by periodontal disease. The syndrome’s appearance results in the term kissing lesions because the injuries are located where the oral mucous membranes rub against the plaque and calculus-laden teeth (Figure 1).2

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