In the United States, gonadectomy is routinely performed in dogs between 4 and 9 months of age.1-3 The decision to perform this procedure is often based on convention, habit, or misconception of health benefits rather than on an evidence-based assessment of each patient.

Following is a discussion of the benefits and potential adverse events of gonadectomy in large- and giant-breed dogs (Table 1). Of note, much of the literature on this topic is retrospective and based on smaller select populations, so relative risk is difficult to determine for individual animals.

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