Juvenile sterile granulomatous dermatitis and lymphadenitis (JSGDL; ie, juvenile cellulitis, juvenile pyoderma, puppy strangles) is a nodular granulomatous inflammatory disorder of unknown pathogenesis for which no microbial organisms have been identified.
Figure 1. (above). Swelling and erosions of the muzzle and periocular area of a male Chihuahua crossbreed (8 weeks of age). Submandibular lymphadenopathy and exudative otitis externa were also noted on examination.
JSGDL most often develops in puppies younger than 4 months of age, although occasional cases in adult dogs have been reported.1 Several puppies from the same litter may be affected. The golden retriever, dachshund, and Gordon setter may be predisposed.
Figure 2. Erythematous and swollen external ear canal and pinna of the puppy in Figure 1.
The initial presenting sign is acute facial swelling and submandibular lymphadenopathy (Figure 1). Less than half of affected puppies exhibit concurrent lethargy or anorexia. Edema of the face, ear, eyelid, and lip margin can be striking. Pustular and nodular lesions follow initial swellings and can develop into erosions or crusting and produce drainage. The external ear canals and pinnae are often thickened and erythematous2(Figure 2).
Initial lesions are sterile, although secondary bacterial infection and sepsis can develop without appropriate treatment. Joint pain and fever have been reported. Primary differentials include pyoderma and demodicosis.
In a young puppy, presumptive diagnosis of JSGDL may be based on acute swelling. Examining cytologic preparations from lesions may reveal pyogranulomatous inflammation without organisms. Culture results in patients with early-stage disease will be negative. Histopathologic tissue examination can reveal granulomatous and pyogranulomatous dermatitis and lymphadenitis, again without identifiable microorganisms.
Without aggressive treatment, lesions can progress to scarring and secondary infection. Most cases respond to oral prednisolone at 2 mg/kg q24h. As lesions resolve, the dose is tapered, usually within 2 to 4 weeks. Oral antibiotics (cephalexin 22 mg/kg q12h, amoxicillin–clavulanic acid 15 mg/kg q12h) are prescribed when secondary pyoderma is suspected. Cyclosporine can be used in chronic or poorly responsive cases.3 Frequent, gentle bathing and soaking with antiseptic solutions (2% chlorhexidine) can reduce discomfort and speed recovery. With early and aggressive treatment, especially before puppies become weakened or secondary infection develops, prognosis for full recovery is excellent. Therapy is often discontinued within 4 to 8 weeks, and relapses are uncommon to rare.
ALEXANDER WERNER, VMD, DACVD, is owner of Animal Dermatology Centers in Studio City and Westlake Village, California, and Reno, Nevada. He has authored dermatology articles and book chapters and lectures nationally. Dr. Werner is coeditor of Blackwell’s Five-Minute Veterinary Consult: Small Animal Dermatology, second edition, and Clinical Companion as well as editor for the next edition. He completed a dermatology residency at University of California, Davis, and earned his degree from University of Pennsylvania.
1. Dermatitis and lymphadenitis resembling juvenile cellulitis in a four year old dog. Neuber AE, van den Broek AHM, Brownstein D, et al. J Small Anim Pract 45:254-258, 2004.
2. Muller and Kirk’s Small Animal Dermatology, 7th ed. Miller WH, Griffin CE, Campbell KL (eds)—St. Louis: Elsevier Mosby, 2013, pp 708-709.
3. Combination of cyclosporine A and prednisolone for juvenile cellulitis concurrent with hindlimb paresis in 3 English cocker spaniel puppies. Park C, Yoo JH, Kim HJ, et al. Can Vet J 51:1265-1268, 2010.
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