Imidacloprid/flumethrin provides an important additional option against fleas and a wide variety of tick species. Imidacloprid/flumethrin is labeled to kill and repel the 4 major tick species that infest dogs and cats in the United States, including Amblyomma americanum, the vector of Cytauxzoon felis.7 In a study of cats, imidacloprid/flumethrin was shown to be 100% effective against Cytauxzoon felis-infected A americanum ticks and is the only flea and tick preventive for cats specifically labeled to kill and repel this tick species.7
Unlike oral and topical isoxazolines, which circulate systemically in the bloodstream, imidacloprid/flumethrin spreads over the surface of the pet’s skin, killing fleas and ticks through contact.2,5,8 Because isoxazolines distribute ingredients in the bloodstream, fleas and ticks must break skin first and feed on blood before they can be killed. As fleas and ticks encounter imidacloprid/flumethrin, however, they become irritated and ataxic, attempting to leave the pet before dying.6 In addition to killing fleas and ticks, imidacloprid/flumethrin also repels them. Repellency is important because if a flea or tick is repelled, it cannot bite and subsequently transmit diseases such as borreliosis, anaplasmosis, and cytauxzoonosis.
Imidacloprid/flumethrin has a fast speed of kill, killing and repelling fleas within 24 hours of application, with new or reinfesting fleas being killed and repelled within 2 hours thereafter.6,7,9 This speed kills fleas before they can lay eggs, a critical component to eliminating flea infestations.6,9 Imidacloprid/flumethrin also kills and repels ticks within 48 hours of application, with new ticks being killed and repelled within 6 hours thereafter, killing ticks through contact often before they have a chance to bite.