• Successful antimicrobial therapy relies on administering sufficient doses so that pathogens at the site of infection are killed or sufficiently suppressed and can be eliminated by the host's immune system.
• Pharmacokinetics (PK) is what the body does to a drug. It is the mathematical description of absorption, distribution to the various tissues, metabolism of lipid-soluble drugs into water-soluble metabolites, and finally renal excretion.
• Pharmacodynamics (PD) is what the antimicrobial agent does to the bacteria. It describes the drug action and responses of the bacteria.
• Pharmacokinetics and pharmacodynamics are interrelated-PK determines the amount of drug that reaches the site of action, and the intensity of a PD effect is associated with the drug concentration at the site of action.
• Benefits of the PK/PD approach include increased efficacy of antimicrobial therapy and minimized antimicrobial resistance.
Sign in to continue reading this article
Not registered? Create an account for free to read full articles on www.cliniciansbrief.com.