March 2016
Oncology
Peer Reviewed

PROFILE

Definition

  • Lymphoma is a diverse, heterogeneous disease that results from the uncontrolled clonal expansion of malignant lymphocytes. 
  • The B-cell phenotype is predominant; the remainder consists of T- or rarely NK-cell phenotypes.1

Lymphoma is generally considered a systemic disease.

Lymphoma is generally considered a systemic disease.

Systems

  • Lymphoma is generally considered a systemic disease. 
  • Sites of origin include lymphoid-rich tissues (ie, lymph nodes, spleen, thymus, bone marrow). 
  • Extranodal sites affected may consist of epithelium, intestinal tract, and CNS. 
    • Because of the systemic nature of this disease, any tissue may be involved. 

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